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Real-time detection of bacteria spores using a QCM based immunosensor

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4 Author(s)
Sang-Hun Lee ; Sch. of Electr. & Comput. Eng., Georgia Inst. of Technol., Atlanta, GA, USA ; Stubbs, D.D. ; Cairney, J. ; Hunt, W.D.

In this paper we present evidence of detection of B. subtilis (non-pathogene models for B. anthracis) spores using a real-time, dual QCM (quartz crystal microbalance) immuno-sensing system. Device sensitivity is achieved through the use of a 10 MHz AT-cut quartz crystal operating in an enclosed flowcell. Specificity is maintained through the use of an immuno-sensing layer consisting of monoclonal antibodies specific to a single Bacillus species. The fidelity of both sensing parameters is ensured by the presence in our system of a reference device coated with an antibody that is not specific for the target antigen. Associating the QCM response signature with the specific binding of a particular species of Bacillus spore to an antibody has implications for future identification of pathogenic endospores such as B. anthracis.

Published in:

Sensors, 2003. Proceedings of IEEE  (Volume:2 )

Date of Conference:

22-24 Oct. 2003

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