By Topic

Design flow enhancements for DNA arrays

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

5 Author(s)
A. B. Kahng ; CSE Dept., California Univ., San Diego, CA, USA ; I. I. Mandoiut ; S. Reda ; X. Xu
more authors

DNA probe arrays have recently emerged as one of the core genomic technologies. Exploiting analogies between manufacturing processes for DNA arrays and for VLSI chips, we demonstrate the potential for transfer of methodologies from the 40-year old field of electronic design automation to the newer DNA array design field. Our main contributions are the following. (1) We give a new design flow for DNA arrays which enhances current methodologies by adding flow-awareness to each optimization step and introducing feedback loops. (2) We propose solution methods for new formulations integrating multiple design steps, including probe selection, placement, and embedding. (3) We give results of a comprehensive experimental study showing that significant improvements in solution quality can be achieved by using the enhanced methodologies.

Published in:

Computer Design, 2003. Proceedings. 21st International Conference on

Date of Conference:

13-15 Oct. 2003