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A mechanistic model of myogenic response

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4 Author(s)
Yang, J. ; Rice Univ., Houston, TX, USA ; Clark, J.W., Jr. ; Bryan, R. ; Robertson, C.

We develop an integrated model of a small arterial resistance vessel, which can mimic its major property of blood flow autoregulation. In the current model, we embed the smooth muscle cell model in a larger compliance-based arterial wall model. The integrated model is used to mimic published pressure-vessel diameter data obtained from isolated resistance vessels that are mounted in a hydraulic test apparatus. The model provides biophysically based insights into the myogenic mechanism as it responds to changes in transmural pressure, in the presence and absence of Ca2+ blockers. It mimics measured data very well and provides a model that is able to link events at subcellular level to macroscopic changes in vessel diameter.

Published in:

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint  (Volume:3 )

Date of Conference:

23-26 Oct. 2002