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An experimental study on human articular cartilage permeability

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7 Author(s)
F. Boschetti ; Lab. of Biol. Struct. Mech., Politecnico di Milano, Milan, Italy ; C. Miotti ; F. Massi ; M. Colombo
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The permeability of cartilage contributes to many tissue functions, like the transport of nutrients to chondrocytes, the ability to carry high loads, and the maintenance of a lubricating fluid film between opposing articular surfaces. We measured in vitro the permeability of the human lateral tibial plateau cartilage through its depth, by measuring the fluid flow induced by an applied pressure gradient; values range from 1.38×10-16 to 8.01×10-16 m4/Ns, showing a decrease with increasing pressure in every layer and a decrease with depth for every level of applied pressure difference. We also extrapolated the permeability values from creep tests performed on the same samples.

Published in:

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint  (Volume:3 )

Date of Conference:

23-26 Oct. 2002