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Synonymous codon usage in genes coding for proteins with different folding types

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5 Author(s)
Wanjun Gu ; Chien-Shiung Wu Lab., Southeast Univ., Nanjing, China ; Jianmin Ma ; Tong Zhou ; Xiao Sun
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195 genes coding for proteins in four different folding types have been analyzed in terms of variance analysis, in which there are 50 genes coding for all alpha proteins, 66 entries for all beta proteins, 37 entries for alpha+beta proteins and 42 entries for alpha/beta proteins. We have observed that codon usage in different gene classes coding for differently folded proteins is significantly different. Similar to amino acid propensities in different protein classes, folding type specific proteins have specific codon usage patterns. With the help of codon usage pattern, we can improve the accuracy of prediction of protein folding type and further prediction of protein secondary structure.

Published in:

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint  (Volume:3 )

Date of Conference:

23-26 Oct. 2002