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Design of a low-voltage instrumentation amplifier for enzyme-extended-gate field effect transistor based urea sensor application

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8 Author(s)
Wen-Yaw Chung ; Inst. of Electron. Eng., Chung Yuan Christian Univ., Chung-li, Taiwan ; Mao-Hsiang Yeh ; Jia-Chyi Chen ; Shen-Kan Hsiung
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This paper presents a low-voltage operated instrumentation amplifier design for enzyme-extended-gate field-effect transistor (EEGFET) biosensor signal readout applications. The instrumentation amplifier built by three bulk-driven amplifiers fabricated in a 0.5 μm double-poly double-metal CMOS technology and other off-chip resistors has been proved to have a potential application in urea sensor signal sensing. Key parameters of the bulk-driven amplifier and the instrumentation amplifier have been verified for the low-voltage signal readout consideration. The system for urea monitoring has been performed with 1.5 V power supply. Experiment results show that the developed instrumentation amplifier has an acceptable sensing response of various urea concentrations in the range of 0.3125 to 240mg/dl

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Electronic Design, Test and Applications, 2002. Proceedings. The First IEEE International Workshop on

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