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Mechanistic investigation of the causes of cellular K+ loss during acute myocardial ischemia: a simulation study

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2 Author(s)
B. Rodriguez ; Departamento de Ingenieria Electroncia, Univ. Politecnica de Valencia, Spain ; J. M. Ferrero

During acute myocardial ischemia, extra-cellular K+ accumulation has been proved to induce re-entrant arrhythmias. Despite the important of this phenomenon, the causes of cellular K+ loss remain still unknown. We investigated the simultaneous effect of the activation of the ATP-sensitive K+ current [IK(ATP) ], the inhibition of the Na+/K+ pump current (INaK) and the appearance of an ischemic Na+ inward current (I0Na) on [K+]0 in the absence of coronary flow using computer modelling. Our results show that the simultaneous activation of these three mechanisms produces a fast increase of [K+]0 during the first 11.6 min, which is mainly due to the enhancement of K+ efflux. Then, [K+ ]0 stabilizes at a plateau level of 15.5 mmol/l. This biphasic time course is qualitatively and quantitatively similar to the increase of [K+]0 observed experimentally

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Computers in Cardiology 2001

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