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Simulation of reentry induced by early afterdepolarizations during acute myocardial ischemia

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3 Author(s)
Colomar, E. ; Laboratorio Integrado de Bioingenieria, Univ. Politecnica de Valencia, Spain ; Ferrero, J.M. ; Saiz, J.

Computer simulations were used to study the conditions which lead to the appearance of ectopic foci and to their propagation as re-entrant activity in partially ischemic tissue. To simulate action potentials, we used a modified version of the Luo-Rudy-II model (C.H. Luo & Y. Rudy, 1994), completed with the formulation of the ATP-sensitive potassium current [IK(ATP)] by J.M. Ferrero et al. (1996). The tissue was simulated as a ring-shaped structure comprising four different regions: early after-depolarizations (EADs), normal zone (NZ), ischemic zone (IZ) and border zone (BZ). Our results show that, when the length of each BZ is 2 mm, [K]0 is 13.5 mmol/l and the length of the NZ is more than 26 mm (260 cells), then ectopic beats appear in the EAD region and they propagate along the tissue, causing re-entry, regardless of the length of the NZ. In conclusion, our theoretical study shows that the co-existence of EAD-condition zones and regional ischemia could set the stage for the appearance of ectopic foci and re-entry

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Computers in Cardiology 2001

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