Scheduled System Maintenance:
On May 6th, single article purchases and IEEE account management will be unavailable from 8:00 AM - 5:00 PM ET (12:00 - 21:00 UTC). We apologize for the inconvenience.
By Topic

Simulation of reentry induced by early afterdepolarizations during acute myocardial ischemia

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
Colomar, E. ; Laboratorio Integrado de Bioingenieria, Univ. Politecnica de Valencia, Spain ; Ferrero, J.M. ; Saiz, J.

Computer simulations were used to study the conditions which lead to the appearance of ectopic foci and to their propagation as re-entrant activity in partially ischemic tissue. To simulate action potentials, we used a modified version of the Luo-Rudy-II model (C.H. Luo & Y. Rudy, 1994), completed with the formulation of the ATP-sensitive potassium current [IK(ATP)] by J.M. Ferrero et al. (1996). The tissue was simulated as a ring-shaped structure comprising four different regions: early after-depolarizations (EADs), normal zone (NZ), ischemic zone (IZ) and border zone (BZ). Our results show that, when the length of each BZ is 2 mm, [K]0 is 13.5 mmol/l and the length of the NZ is more than 26 mm (260 cells), then ectopic beats appear in the EAD region and they propagate along the tissue, causing re-entry, regardless of the length of the NZ. In conclusion, our theoretical study shows that the co-existence of EAD-condition zones and regional ischemia could set the stage for the appearance of ectopic foci and re-entry

Published in:

Computers in Cardiology 2001

Date of Conference:

2001