By Topic

Searching online journals for fluorescence microscope images depicting protein subcellular location patterns

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

The purchase and pricing options are temporarily unavailable. Please try again later.
4 Author(s)
Murphy, R.F. ; Dept. of Biol. Sci., Carnegie Mellon Univ., Pittsburgh, PA, USA ; Velliste, M. ; Jie Yao ; Porreca, G.

There is extensive interest in automating the collection, organization and analysis of biological data. Data in the form of images present special challenges for such efforts. Since fluorescence microscope images are a primary source of information about the location of proteins within cells, we have set as a long-term goal the building of a knowledge base system that can interpret such images in online journals. To this end, we first developed a robot that searches online journals and finds fluorescence microscope images of individual cells. We then characterized the applicability of pattern classification methods we have previously used on images obtained under controlled conditions to images from different sources and to images subjected to manipulations commonly performed during publication. The results indicate the feasibility of developing search engines to find fluorescence microscope images depicting particular subcellular patterns

Published in:

Bioinformatics and Bioengineering Conference, 2001. Proceedings of the IEEE 2nd International Symposium on

Date of Conference:

4-6 Nov 2001