By Topic

Scheduling of microfluidic operations for reconfigurable two-dimensional electrowetting arrays

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
Jie Ding ; Dept. of Electr. & Comput. Eng., Duke Univ., Durham, NC, USA ; K. Chakrabarty ; R. B. Fair

We present an architectural design and optimization methodology for performing biochemical reactions using two-dimensional (2-D) electrowetting arrays. We define a set of basic microfluidic operations and leverage electronic design automation principles for system partitioning, resource allocation, and operation scheduling. Fluidic operations are carried out through the electrostatic configuration of a set of grid points. While concurrency is desirable to minimize processing time, the size of the 2-D array limits the number of concurrent operations of any type. Furthermore, functional dependencies between the operations also limit concurrency. We use integer linear programming to minimize the processing time by automatically extracting parallelism from a biochemical assay. As a case study, we apply our optimization method to the polymerase chain reaction, which is an important step in many lab-on-a-chip biochemical applications

Published in:

IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems  (Volume:20 ,  Issue: 12 )