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Design of integrated microfluidic device for sorting magnetic beads in biological assays

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7 Author(s)
Tondra, Mark ; NVE Corp., Eden Prairie, MN, USA ; Granger, M. ; Fuerst, R. ; Porter, Marc
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On-chip manipulation of nanoscopic magnetic particles in microfluidic channels has been demonstrated. The particles, obtained from Bangs Labs, were 460 nm in diameter and contained 12% ferrite. They were moving in a 12 μm wide by 4 μm deep channel etched into a deposited layer of silicon nitride. An Al current strap was buried beneath the channel and shaped in such a way to generate an in-plane cross-channel field gradient when it was energized by an electrical current. An in-plane external field of 20 kA/m was applied in order to magnetize the particles. They were observed to move across the channel as either the current or field polarity was changed

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Magnetics, IEEE Transactions on  (Volume:37 ,  Issue: 4 )