Cart (Loading....) | Create Account
Close category search window
 

Optimal design of experiments for estimating arterial wall transport parameters

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
Morris, E.D. ; Dept. of Biomed. Center, Case Western Res. Univ., Cleveland, OH, USA ; Saidel, G. ; Chisolm, G.M., III

Atherosclerosis is associated with an accumulation of low-density lipoprotein (LDL) in the arterial wall. To quantify transport processes involved in this phenomenon, tracer experiments are performed by exposing the arterial wall to labeled LDL. Distributed mathematical models are needed to describe the resulting LDL profiles in the tissue. Parameter values can be estimated by fitting model-generated profiles to experimental data. The authors believe that in vivo parameter estimates can be made more practical through the application of optimal experiment design analysis. Their analysis was based on an examination of the sensitivity coefficients and the Hessian matrix. Two experiment designs were considered. The findings indicate that it is possible to improve the precision of the estimates of in vivo transport parameters by designing experiments which use a labeled LDL tracer and a distinguishable, labeled LDL, chemically modified with tyramine-cellobiose.<>

Published in:

Engineering in Medicine and Biology Society, 1988. Proceedings of the Annual International Conference of the IEEE

Date of Conference:

4-7 Nov. 1988

Need Help?


IEEE Advancing Technology for Humanity About IEEE Xplore | Contact | Help | Terms of Use | Nondiscrimination Policy | Site Map | Privacy & Opting Out of Cookies

A not-for-profit organization, IEEE is the world's largest professional association for the advancement of technology.
© Copyright 2014 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.