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High-speed solution switching using piezo-based micropositioning stages

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3 Author(s)
S. Stilson ; Dept. of Mech. Eng., Utah Univ., Salt Lake City, UT, USA ; A. McClellan ; S. Devasia

Motion-induced vibration is a critical limitation in high-speed micropositioning stages used to achieve solution switching. Controlled rapid solution switching is used to study the fast activation and deactivation kinetics of ligand-gated ion-channel populations isolated in excised membrane patches-such studies are needed to understand fundamental mechanisms that mediate synaptic elicitation and inhibition in the central nervous system. However, as the solution-switching speed is increased, vibration induced in the piezo-based positioning stages can result in undesired, repeated, ligand application to the excised patch. The article describes a method to use knowledge of the piezo-stage's vibrational dynamics to compensate for and reduce these unwanted vibrations. The method was experimentally verified using an open-electrode technique, and fast solution switching (100 μs range) was achieved.

Published in:

IEEE Transactions on Biomedical Engineering  (Volume:48 ,  Issue: 7 )