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Feedback control of a biodynamical model of HIV-1

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2 Author(s)
Brandt, M.E. ; Health & Sci. Center, Texas Univ., Houston, TX, USA ; Guanrong Chen

Describes a continuous differential equation model of the interaction dynamics of HIV-1 and CD4 and CD8 lymphocytes in the human body. The authors demonstrate several methods of stable control of the HIV-1 population using an external feedback control term that is analogous to the introduction of a therapeutic drug regimen. They also show how the immune system components can be bolstered against the virus through a feedback control approach.

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Biomedical Engineering, IEEE Transactions on  (Volume:48 ,  Issue: 7 )