By Topic

In vivo droplet vaporization using diagnostic ultrasound-a potential method for occlusion therapy?

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

5 Author(s)
Kripfgans, O.D. ; Dept. of Radiol., Michigan Univ. Health Syst., Ann Arbor, MI, USA ; Fowlkes, J.B. ; Eldevik, O.P. ; Carson, P.L.
more authors

The experimental objective was to determine whether a transpulmonary droplet emulsion (90%<6 μm diameter) can be used to temporarily form large gas bubbles (>30 μm) which would be utilized to occlude the capillary bed of tissue. Gas bubbles can be made in vivo to potentially block capillaries, by acoustic droplet vaporization (ADV) of injected, superheated, dodecafluoropentane droplets. Droplets evaporate into gas bubbles when exposed to an acoustic field who's peak rarefactional pressure exceeds a well defined threshold. It has been found that I.A. as well as I.V. injections can be used to introduce the emulsion into the blood stream and subsequently perform ADV (using B- and M-mode on a clinical ultrasound scanner) at the target site. I.V. administration results in a lower gas bubble yield, possibly due to droplet filtering in the lung, dilution in the blood volume or other circulatory effects

Published in:

Ultrasonics Symposium, 2000 IEEE  (Volume:2 )

Date of Conference:

Oct 2000