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Quantitative dynamic imaging of biological processes with solid state radiation detector

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8 Author(s)
Abate, L. ; Dipartimento di Sci. Fisiche, Naples Univ., Italy ; Bertolucci, E. ; Conti, M. ; Di Cosmo, A.
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The authors have developed a technique and a prototype for β-ray quantitative imaging of biological samples which have been radioactively labeled. The prototype is based on a solid state pixel detector, bump-bonded to a low threshold, single particle counting chip: the detector the authors used is 200-μm thick GaAs, with pixel size 170 μm. Here, they describe an experiment that shows the capability of monitoring a dynamic process. Specifically, [14C]L-Leucine uptake by eggs of mollusk cephalopod Octopus culgaris and the consequent migration of marker into the ooplasm was followed

Published in:

Nuclear Science, IEEE Transactions on  (Volume:47 ,  Issue: 6 )

Date of Publication:

Dec 2000

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