By Topic

Molecular interactions between lipid and paclitaxel (Taxol(R) ) within cell membrane simulated by the lipid monolayer at the air-water interface

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

4 Author(s)
Ke Gong ; Dept. of Chem. & Environ. Eng., Nat. Univ. of Singapore, Singapore ; Si-Shen Feng ; Jolynn Chew ; Lingyun Zhao

Paclitaxel (Taxol(R)) is a novel antineoplastic drug with a high potency against advanced ovarian and breast cancer. However, clinical application has been hampered by the poor aqueous solubility of taxol, which necessitates administration of the drug in excipients (Cremophor EL and ethanol). These adjvants cause a variety of side effects, including anaphylactoid hypersensitivity reactions. Recently, Taxol has been formulated in better-tolerable drug carriers such as liposomes. In this paper we use the lipid monolayer at the air-water interface to simulate the bilayer vesicles and the cell membrane in characterization of the molecular interaction between Taxol and phospholipid (DPPC) within the membrane. It was found that at 25°C the penetration of Taxol into DPPC membrane alters the surface pressure dramatically, especially in low molar ratio of Taxol:DPPC (<1:2). Penetration kinetics studies showed that Taxol molecules have intensive interaction with DPPC monolayer. The critical surface pressure for Taxol molecules to partition into the DPPC membrane is around 31 mN/m

Published in:

Engineering in Medicine and Biology Society, 2000. Proceedings of the 22nd Annual International Conference of the IEEE  (Volume:3 )

Date of Conference: