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The intravenous route to blood glucose control

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3 Author(s)
Parker, R.S. ; Dept. of Chem. Eng., Delaware Univ., Newark, DE, USA ; Doyle, F.J. ; Peppas, N.A.

This article discusses closed-loop blood glucose regulation algorithms that use the intravenous route for insulin delivery to insulin-dependent diabetic patients. Classical control methods and advanced algorithms using implicit knowledge or explicit models (empirical, fundamental, or “gray-box”) of the diabetic patient are examined. Current research on characterizing patient variability is presented, in the context of a model predictive controller able to adjust to changes in patient glucose and insulin sensitivity

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Engineering in Medicine and Biology Magazine, IEEE  (Volume:20 ,  Issue: 1 )