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Suppressing arrhythmias in cardiac models with overdrive pacing

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3 Author(s)
G. V. Osipov ; Dept. of Radiophys., Univ. of Nizhny Novgorod, Russia ; A. T. Stamp ; J. J. Collins

Recent findings indicate that fibrillating cardiac tissue arises from spiral wave chaos. Here we show that spiral wave chaos can be suppressed in a cardiac model by pacing the system with low-amplitude, high-frequency current pulses. This overdrive pacing technique is analyzed using a one-dimensional chain and a two-dimensional lattice of coupled, excitable elements with the kinetics described by the Luo-Rudy action potential model (1991). When two-dimensional media were excited with frequencies from 1:1 synchronization region, we found that spiral wave chaos could be suppressed in a limited number of cases. However, when used in conjunction with calcium channel blockers, high-frequency pacing suppressed spiral wave chaos in all episodes. These findings suggest that low-amplitude overdrive pacing in combination with class IV antiarrhythmic drugs, inhibitors of calcium channels, may be useful for eliminating fibrillation in cardiac tissue

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Control of Oscillations and Chaos, 2000. Proceedings. 2000 2nd International Conference  (Volume:3 )

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