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Automatic registration of postmortem brain slices to MRI reference volume

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5 Author(s)
Kim, T.-S. ; Dept. of Radiol. & Biomed. Eng., Univ. of Southern California, CA, USA ; Singh, M. ; Sungkarat, W. ; Zarow, C.
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A new strategy to register each slice of the postmortem brain to anatomically corresponding in-vivo MRI slices is presented. The approach relies on a recursive reslicing of the FVIRI volume using non-linear polynomial transformations. Simulation studies to validate the approach and results using real data are presented. The results suggest the feasibility and practicability of second- and third-order polynomials to register postmortem images on a slice-by-slice basis to corresponding MRI sections. Using this method, it is possible to investigate the pathology of a disease through routinely acquired MRIs and postmortem brain images

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Nuclear Science, IEEE Transactions on  (Volume:47 ,  Issue: 4 )