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An integrated liquid mixer/valve

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3 Author(s)
Voldman, J. ; Dept. of Electr. Eng. & Comput. Sci., MIT, Cambridge, MA, USA ; Gray, M.L. ; Schmidt, M.A.

We present an integrated liquid mixer/valve to be used for sample preparation for bioscience analysis systems. The mixer/valve is a glass-silicon bonded structure with a wafer-bonded cantilever-plate flapper valve and deep reactive-ion etched ports. It is passively pressure actuated and is distinguished by the fact that it can perform both a mixing and valving function simultaneously to mix two liquids noncontinuously. We present the design and fabrication of the mixer/valve and show that it successfully performs both its valving and mixing functions, including the discontinuous mixing of two liquids. We propose a method for characterizing mixing in this device using fluorescence microscopy and the pH dependence of fluorescein fluorescence. This method aims to allow one to extract the mixing length from a quantifiable observable. We present modeling and results of mixing length measurements using this method.

Published in:

Microelectromechanical Systems, Journal of  (Volume:9 ,  Issue: 3 )

Date of Publication:

Sept. 2000

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