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A novel method for long-term recording and simulation applicable to cultured neurons has been developed. Silicon-based microelectrodes have been fabricated using integrated-circuit technology and micromachining. The chronic connection is made by positioning the tip of the 'diving-board electrode' into contact with the top of the cell body. The electrode support structure is then glued to the bottom of the culture dish. Two-way electrical connections to Helisoma B19 neurons have been maintained for up to four days. This capability makes it possible to conduct experiments that are not practical using conventional techniques.
Date of Publication: Dec. 1988