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Absolute in vivo quantitation of myocardial activity

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6 Author(s)
A. J. Da Silva ; Dept. of Radiol., California Univ., San Francisco, CA, USA ; H. R. Tang ; K. H. Wong ; M. C. Wu
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Quantitation of myocardial SPECT images corrected for attenuation underestimates the true radionuclide content due to partial volume errors. To measure radionuclide uptake more accurately, the authors have developed a technique to compensate these images for partial volume errors using coregistered X-ray CT images. The CT image is used to define a template that approximates the geometrical extent of the myocardium. Once defined, the template is assigned unit activity and is mathematically projected using a realistic physical model of the radionuclide imaging process. These projections are then reconstructed and used to compensate the SPECT image for partial volume errors. The method was tested in a porcine model of myocardial perfusion using Tc-99m sestamibi. With attenuation correction alone, the in vivo activity concentration in the porcine myocardium had an error in the range -40% to -60% compared to the true activity concentration. Correcting for partial volume errors, the in vivo activity concentration was determined to within 10% of the true value. By also correcting for partial volume errors, the in vivo activity concentration was determined to within 10% of the true value

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IEEE Transactions on Nuclear Science  (Volume:47 ,  Issue: 3 )