By Topic

Attenuation and scatter correction in brain SPECT with Tc-99m labeled receptor-specific radiopharmaceuticals

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
Jang, S. ; Dept. of Radiol., Pennsylvania Univ., Philadelphia, PA, USA ; Mozley, P.D. ; Barraclough, E.D.

The main aim of this study was to evaluate the effects of attenuation correction (AC), scatter correction (SC) and collimator resolution on neuroreceptor and neurotransporter imaging using Tc-99m labeled compounds. Accurate measurement of the ratios of target-to-background counts is key for the evaluation of several neuropsychiatric diseases with neuroimaging. For simultaneous emission-transmission scans, a triple-head camera system with a Gd-153 line source was used with low energy high resolution fan beam (LEHR-FB) or ultra-high resolution FB (LEUHR-FB) collimators. Striatal phantom data were acquired with 4, 8 and 12 times the concentration of the background Tc-99m activity and were processed using no correction, uniform AC with a single iteration Chang (UAC), non-uniform AC, and AC+SC. After post-filtering the data, basal ganglia-to-background (BG/B) ratios were calculated using an region-of-interest (ROI) punch biopsy method. In general, the LEUHR-FB collimator produced higher BG/B ratios than the LEHR-FB collimator. Overall, the AC+SC method yielded the most accurate ratios, although the differences in the four processing methods were relatively small

Published in:

Nuclear Science Symposium, 1999. Conference Record. 1999 IEEE  (Volume:3 )

Date of Conference: