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Determination of intracranial tumor volumes in a rodent brain using magnetic resonance imaging, Evans Blue, and histology: a comparative study

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5 Author(s)
Prabhu, S.S. ; Div. of Neurosurg., Virginia Commonwealth Univ., Richmond, VA, USA ; Broaddus, W.C. ; Oveissi, C. ; Berr, S.S.
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The measurement of tumor volumes is a practical and objective method of assessing the efficacy of a therapeutic agent. However, the relative accuracy of different methods of assessing tumor volume has been unclear. Using T 1-weighted, gadolinium-enhanced magnetic resonance imaging (T 1-MRI), Evans Blue infusion and histology the authors measured intracranial tumor volumes in a rodent brain tumor model (RT2) at days 10, 16 and 18 after implantation of cells in the caudate putamen. There is a good correlation between tumor volumes comparing T 1-MRI and Evans Blue (r 2=0.99), T 1-MRI and histology (r 2=0.98) and histology and Evans Blue (r 2=0.93). Each of these methods is reliable in estimating tumor volumes in laboratory animals. There was significant uptake of gadolinium and Evans Blue in the tumor suggesting a wide disruption of the blood-brain barrier.

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Biomedical Engineering, IEEE Transactions on  (Volume:47 ,  Issue: 2 )