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MRI simulation-based evaluation of image-processing and classification methods

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3 Author(s)
Kwan, R.K.-S. ; McConnell Brain Imaging Centre, McGill Univ., Montreal, Que., Canada ; Evans, A.C. ; Pike, G.B.

With the increased interest in computer-aided image analysis methods, there is a greater need for objective methods of algorithm evaluation. Validation of in vivo MRI studies is complicated by a lack of reference data and the difficulty of constructing anatomically realistic physical phantoms. The authors present here an extensible MRI simulator that efficiently generates realistic three-dimensional (3-D) brain images using a hybrid Bloch equation and tissue template simulation that accounts for image contrast, partial volume, and noise. This allows image analysis methods to be evaluated with controlled degradations of image data.

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Medical Imaging, IEEE Transactions on  (Volume:18 ,  Issue: 11 )