By Topic

On the road toward electronic biosensors

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

1 Author(s)
L. L. Sohn ; Dept. of Phys., Princeton Univ., NJ, USA

Summary form only received as follows: Recent advances in nanofabrication technology have allowed for access to length scales in the sub-20 nm regime. Since such length scales are compatible with many biological systems, including DNA and proteins, it is now possible to consider the integration of nanofabrication technology with molecular biology. Using electron-beam lithography and advanced resist technology, the author has fabricated electronic sensors on silicon that can detect and manipulate single biomolecules, i.e. DNA and proteins. Specifically, the author's sensors consist of arrays of platinum nano-electrodes which form channels, 10 nm wide and several microns long, When individually voltage-biased, the nanoelectrodes can manipulate single molecules of DNA within a confined geometry. Via capacitance measurements, the nanoelectrodes can detect the presence of single molecules and ascertain their length by time-of-flight measurements. The electronic sensors the author has fabricated are first-generation. That they can already detect and manipulate single biomolecules-all on silicon-suggest that future devices will be truly hybrid in nature, serving many functions on both the molecular biology and electronic level

Published in:

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint  (Volume:2 )

Date of Conference:

Oct 1999