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Mechanical strain reduces osteoclast recruitment by targeting gene expression

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4 Author(s)
Rubin, J. ; Dept. of Med., Emory Univ. Sch. of Med., Atlanta, GA, USA ; Murphy, T. ; Nanes, M. ; Xian Fan

Normal dynamic loading prevents bone resorption; however, the means whereby biophysical factors reduce osteoclast activity is not understood. The authors show here that mechanical strain applied to murine marrow cultures reduced osteoclast formation by 50%. The reduction in osteoclast formation was preceded by decreased stromal cell expression of osteoclast differentiation factor (ODF/TRANCE). Since osteoclast formation is critically dependent upon ODFT/TRANCE expression, a strain-induced reduction in this factor may contribute to reduced osteoclastogenesis

Published in:

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint  (Volume:2 )

Date of Conference:

Oct 1999