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Closed-loop analysis of heart rate variability in obstructive sleep apnea

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3 Author(s)
Khoo, M.C.K. ; Dept. of Biomed. Eng., Univ. of Southern California, Los Angeles, CA, USA ; Belozeroff, V. ; Berry, R.B.

We have developed a model-based approach for assessing autonomic function in patients with obstructive sleep apnea syndrome (OSA). A closed-loop minimal model of cardiorespiratory control was estimated from RR-interval and respiration measured during a randomized breathing protocol. Application of the algorithm to simulated data confirmed the feasibility of estimating the model parameters under closed-loop conditions. Significant differences in the morphology and magnitude of the impulse response of one of the model components were found in OSA versus normal subjects. The results suggest that this procedure may provide a more sensitive means of detecting and tracking changes in autonomic function in patients before and during therapy for OSA

Published in:

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint  (Volume:2 )

Date of Conference:

Oct 1999