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Poloxamer-188 improves capillary blood flow in the zone of stasis after burn injury

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3 Author(s)
Baskaran, H. ; Harvard Med. Sch., Boston, MA, USA ; Yarmosh, M. ; Berthiaume, F.

Cutaneous burn injury causes blood flow reduction in regions near the site of the injury, collectively termed as the zone of stasis. Blood flow, in this zone, ceases after 24-48 hours resulting in an expansion of the injured area. The authors used intravital microscopy to investigate the zone of stasis. CD-1 male mice (30 g) were fitted with skin flap chambers and capillary blood flow was visualized by intravenously injecting fluorescently labeled red blood cells into the mice. A temperature-controlled copper tip of 2 mm diameter was used to inflict a full-thickness burn injury on the mouse skin. Real time fluorescent images of the blood flow before and after the burn were recorded. Playback image analysis showed that there was a reduction in blood flow near the site of burn injury immediately (0-2 hrs.) after the injury and away from the site of injury there was no change. Intravenous injection of Poloxamer-188 (0.1 ml, 200 mg/kg) greatly improved blood flow in the zone of stasis

Published in:

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint  (Volume:2 )

Date of Conference:

Oct 1999

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