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Derivation of the diastolic left ventricular wall-thinning to transmitral flow-velocity relation: validation by model-based image processing

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4 Author(s)
Sessoms, M.W. ; Cardiovascular Biophys. Lab., Washington Univ. Sch. of Med., St. Louis, MO, USA ; Milde, J.M. ; Lisauskas, J.B. ; Kovacs, S.J.

The echocardiographically measured maximal rate of left ventricular (LV) wall-thinning in early diastole has been proposed as a new index of diastolic function. However, its causal relationship to transmitral filling velocity (Doppler E-waves) has not been established. We derived the ventricular wall-thinning to filling relation, using the constant volume of the 4-chamber heart. Left atrio-ventricular geometry was modeled as a constant volume cylinder having a semi-ellipsoid apex and constant external surface. For validation E-wave and color M-Mode images of LV wall thinning were compared to the model predicted filling-velocity to wall-thinning relation. Excellent agreement was observed. We conclude that reasonable assumptions of LV geometry and conservation of volume establish the LV wall-thinning to filling-velocity (Doppler E-wave) relation. Hence, a global, wall-thinning derived diastolic function index is derivable from the transmitral flow velocity (the Doppler E-wave)

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[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint  (Volume:1 )

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