Referenced Items are not available for this document.
Adhesion of cells to the substratum is critical for cell migration. The authors have developed a three-dimensional migration assay consisting of collagen covalently coupled with RGD peptides to directly measure cell migration as a function of substratum adhesiveness. The random motility coefficient, a measure of the rate of cell dispersion by random migration, was found to have a biphasic dependence on increasing adhesiveness. To further understand the different modes of cell motility observed, a mechanistic model has been developed which predicts stochastic multi-dimensional cell migration as a function of receptor-ligand binding kinetics and pseudopod protrusion and retraction dynamics. Model predictions agree with the experimental results
Published in:
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
(Volume:1
)
Date of Conference: 1999
- Meeting Date :
- 13 Oct 1999-16 Oct 1999
- ISSN :
- 1094-687X
- Print ISBN:
- 0-7803-5674-8
- INSPEC Accession Number:
- 6441620
- Conference Location :
- Atlanta, GA
- Digital Object Identifier :
- 10.1109/IEMBS.1999.802140
- Product Type:
- Conference Publications
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