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Effects of shear stress on tissue factor gene expression in endothelial cells

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3 Author(s)
Lin, K. ; Dept. of Bioeng. & Inst. of Biomed. Eng., California Univ., San Diego, La Jolla, CA, USA ; Shyy, Y.-J. ; Shu Chien

Studying the effects of shear stress on the expression of tissue factor (TF) gene in cultured endothelial cells (ECs), the authors found that a GC-rich region of the promoter that contains EGR-1 and Sp1 sites is responsible for the shear stress induction of TF gene. The increased transcriptional activity is mediated through a novel mechanism of Sp1 phosphorylation, rather than DNA binding

Published in:

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint  (Volume:1 )

Date of Conference:

1999

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