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mRNA expression of extracellular matrix proteins following exposure of bladder smooth muscle cells to sustained hydrostatic pressure

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3 Author(s)
Haberstroh, K.M. ; Dept. of Biomed. Eng., Rensselaer Polytech. Inst., Troy, NY, USA ; Kaefer, M. ; Bizios, R.

The bladder responds to, functions under, and is controlled by mechanical forces. In vivo, pathological conditions involving elevated pressures within the bladder have been associated with increased amounts of extracellular matrix production and decreased bladder tissue compliance. The present in vitro cellular model was designed to simulate conditions pertinent to bladder function at the cellular/molecular level and examined the responses of bladder smooth muscle cells to sustained hydrostatic pressure. Specifically, the transcription of extracellular matrix proteins (such as collagen and laminin) were monitored following exposure of bladder smooth muscle cells to sustained hydrostatic pressure

Published in:

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint  (Volume:1 )

Date of Conference:

1999