Cart (Loading....) | Create Account
Close category search window
 

A model of the electrochemical equilibrium configuration of the capillary glycocalyx

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
Stace, T.M. ; Dept. of Mech. Eng., Western Australia Univ., Nedlands, WA, Australia ; Pushkin, D.O. ; Damiano, E.R.

A electrochemical theory of the surface glycocalyx on capillary endothelial cells is presented which models the structure as a matrix of electrostatically charged macromolecules hydrated in an electrolytic Newtonian fluid. In equilibrium it is assumed that a state of electroneutrality exists such that positively charged ions in the fluid balance the fixed negative charges bound to the macromolecules of the glycocalyx. Disturbances arising from mechanical deformation, flow, and chemical and/or electric potentials are introduced as perturbations away from the electroneutral equilibrium environment. In the presence of charged fluorescent macromolecules injected into the capillary lumen, the model predicts that chemical and electric potentials would result in a flux of ions and macromolecules into the layer at size- and charge-dependent rates until a new electroneutral environment is achieved that is in equilibrium with the solution in the capillary lumen. Model predictions are compared with experimental results and used to estimate the fixed-charge density of tile solid-bound charges in the endothelial-cell glycocalyx and the state of tension in the solid matrix in the equilibrium configuration

Published in:

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint  (Volume:1 )

Date of Conference:

1999

Need Help?


IEEE Advancing Technology for Humanity About IEEE Xplore | Contact | Help | Terms of Use | Nondiscrimination Policy | Site Map | Privacy & Opting Out of Cookies

A not-for-profit organization, IEEE is the world's largest professional association for the advancement of technology.
© Copyright 2014 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.