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Introduces a new model for multiscale analysis of space-time echocardiographic sequences. The proposed nonlinear partial differential equation, representing the multiscale analysis, filters the sequence while keeping the space-time coherent structures. It combines the ideas of regularized Perona-Malik anisotropic diffusion and the Galilean invariant movie multiscale analysis of Alvarez et al. (Arch. Rat. Mech. Anal., vol. 123, p. 200-57, 1993). A numerical method for solving the proposed partial differential equation is suggested and its stability is shown. Computational results on synthesized and real sequences are provided. A qualitative and quantitative evaluation of the accuracy of the method is presented.