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Regional left ventricular function from short SPECT gated blood pool studies

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4 Author(s)

SPECT gated blood pool scans can provide accurate 3D assessments of resting regional left-ventricular (LV) function. However, due to limited scan times for stress studies, SPECT GBP images are too noisy for standard visual analysis. In this study, a counts-based scheme for measuring regional ejection fraction (REF) and relative regional phase (RRP) was investigated. Constructing a rest normal database from the 30-min. SPECT GBPs of 10 volunteers, the mean and standard deviation (σ(rest NLDB)) of these parameters was calculated for each of 12 3D regions. Adding statistical noise, the expected normal database variability at stress (σstress NLDB) from 3-min. scans was estimated for each parameter. The variability due only to increased noise (σnoise) was an average of 15% of the total σstress NLDB for REF and 30% for RRP. Analyzing rest scans from two patients with regional defects, regions were classified twice; first based on a criterion of ±2σ rest NLDB about the average normal database value for that region, then, again, using ±2σstress NLDB. Of the 19 abnormal regions identified at rest, 18 were still detected with the ±2σstress NLDB criterion. This suggests that quantitative regional analysts may be relatively insensitive to the increased noise from a 3-min. scan, making stress SPECT GBP studies potentially feasible

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Nuclear Science Symposium, 1998. Conference Record. 1998 IEEE  (Volume:3 )

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