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Cuff electrodes for recording of the electro-neurogram from peripheral nerves were introduced by Hoffer  and Stein, et al. . The cuffs were used to obtain higher signal amplitudes than previously possible, at least in chronic recordings, and to decrease the pick-up of noise, especially from muscles. Cuff electrodes are relatively stable in long-term recordings, but the stability has never been quantified in terms of input-output relationships; i.e., in terms of responses to repeatable stimuli over time. Moreover. The relationship between nerve damage and electrophysiological parameters has never been assessed. In this article, after reviewing the development of cuff electrodes and their applications, we present a long-term study of tactile peripheral nerve signals, electrically activated nerve signals, and impedance measurements. We show how the recordings vary over a 16-month period after implantation of nerve cuff electrodes in rabbits, and how nerve damage is reflected in the recorded signals.