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Singular stimulus parameters to annihilate spontaneous activity in Hodgkin-Huxley model with elevated potassium

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3 Author(s)
Jahangiri, A. ; Neural Eng. Lab., Case Western Reserve Univ., Cleveland, OH, USA ; Durand, D.M. ; Jian-Cheng Lin

A algorithm is presented to predict the intensity and timing of a single stimulus required to annihilate spontaneously occurring action potentials in the Hodgkin-Huxley model. Elevation of the potassium equilibrium potential causes oscillations in the V, m, h and n parameters. Equations describing the time-varying behavior of these parameters can be used predict the pulse width, coupling interval of a single anodic pulse applied two consecutive action potentials the activity. Results showed that with the estimated parameters was able to completely annihilate the action potentials

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Engineering in Medicine and Biology Society, 1997. Proceedings of the 19th Annual International Conference of the IEEE  (Volume:5 )

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