Cart (Loading....) | Create Account
Close category search window
 

Concurrent acquisition of hippocampal neurochemical and electrophysiological measures from freely moving rats

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

6 Author(s)
Bronzino, J.D. ; Dept. of Eng., Trinity Coll., Hartford, CT, USA ; Austin-LaFrance, R.J. ; Watson, V. ; King, Y.
more authors

The authors have recently developed surgical and recording procedures which allow them to monitor levels of select neurochemicals (via microdialysis) simultaneous with measures of neuronal excitability (evoked response measures) within the hippocampal formation of freely moving adult rats. These procedures were employed to examine changes in hippocampal neurochemistry and neuronal excitability associated with the establishment, maintenance, and decay of hippocampal long-term potentiation (LTP). Measures of hippocampal norepinephrine (NE) levels along with measures of the dentate granule cell population spike amplitude (PSA) were obtained before, during, and after tetanization of the medial perforant using two separate tetanization paradigms. Results indicated that changes in NE levels following tetanization were strongly correlated with changes in the dentate granule cell PSA measure. The results indicate that this newly developed procedure can be effectively used to directly examine the relationship between neurochemical and neurophysiological changes associated with hippocampal neuroplasticity

Published in:

Engineering in Medicine and Biology Society, 1997. Proceedings of the 19th Annual International Conference of the IEEE  (Volume:3 )

Date of Conference:

30 Oct-2 Nov 1997

Need Help?


IEEE Advancing Technology for Humanity About IEEE Xplore | Contact | Help | Terms of Use | Nondiscrimination Policy | Site Map | Privacy & Opting Out of Cookies

A not-for-profit organization, IEEE is the world's largest professional association for the advancement of technology.
© Copyright 2014 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.