By Topic

Reflection and ectopic activity induced by early after depolarizations. A computer modeling study

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

7 Author(s)
J. Saiz ; Lab. Integrado de Bioingenieria, Univ. Politecnica de Valencia, Spain ; M. Monserrat ; J. Gomis ; V. Torres
more authors

A computer model of two partially coupled ventricular fibers was used to study conditions in which EADs developed in an area of ventricular myocardium propagate to other areas, generating ectopic activity or reflection. We simulate the interactions between two areas of myocardium coupled through an area of unexcitable tissue, simulated by a resistance R. EADs are induced in one of the segments by enhancing ICa current and decreasing IK current while the other is kept under normal conditions. The results show that the likelihood of ectopic activity and reflection depends on both EAD conditions and R values. For low values of R (in the range from 5 Ω·cm2 to 10 Ω·cm2) ectopic activity and reflection only appear for strong EAD conditions (I Ca enhanced by 80% and IK blocked by 80%). However, when higher R values are used, the ectopic activity and reflection appear at less extreme EAD conditions. For R=50 Ω·cm2, both phenomena appear for ICa enhanced by 60% and IK blocked by 60%. The study shows that ectopic activity and reflection in a zone of myocardium could be induced by EADs generated in neighboring zones

Published in:

Engineering in Medicine and Biology Society, 1998. Proceedings of the 20th Annual International Conference of the IEEE  (Volume:6 )

Date of Conference:

29 Oct-1 Nov 1998