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Cellular engineering: crash tests on human erythrocytes reveal hidden material properties of cellular proteins

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5 Author(s)
Artmann, G.M. ; Dept. of Cell Biophys., Aachen Univ. of Appl. Sci., Julich, Germany ; Kelemen, C. ; Porst, D. ; Buldt, C.
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Human red blood cells (RBC) undergo a sudden change from blocking to passing through 1-μm-micropipettes at a transition temperature (Tc) of 36.4°C. For resealed RBC-ghosts this transition occurs at 28.3°C (Tg). These findings are attributed to elastomeric transitions of hemoglobin from being gel-like to a fluid and of membrane proteins such as spectrin

Published in:

Engineering in Medicine and Biology Society, 1998. Proceedings of the 20th Annual International Conference of the IEEE  (Volume:6 )

Date of Conference:

29 Oct-1 Nov 1998