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Correction of time-intensity curves for tissue perfusion evaluation using ultrasound contrast agent

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3 Author(s)
Li Li ; Dept. of Biomed. Eng., Xi''an Jiaotong Univ., China ; Wan Mingxi ; Gheng Jingzhi

Instability of scattering of ultrasound contrast agents (UCA) during their interaction with flowing blood will modify their time-intensity curves, which imposes a limitation on the ability of time-intensity curves for UCA aided tissue perfusion evaluation. A direct correction method, using the varying scattering of UCA as a function of time, is proposed and verified with an in vitro flow model and in vivo studies on six anesthetized open-chest dogs. The result of the experiment demonstrates that the homemade UCA is efficient, and the parameters derived from the corrected time-intensity, especially areas under the curve, are more closely correlated with myocardial ischemic degree. This method appears to be a useful addition to existing clinical techniques for quantifying tissue perfusion with UCA

Published in:

Engineering in Medicine and Biology Society, 1998. Proceedings of the 20th Annual International Conference of the IEEE  (Volume:2 )

Date of Conference:

29 Oct-1 Nov 1998