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Development of a novel radiation imaging detector system for in vivo gene imaging in small animal studies

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4 Author(s)
Weisenberger, A.G. ; Detector Group, Thomas Jefferson Nat. Accel. Fac., Newport News, VA, USA ; Bradley, E.L. ; Majewski, S. ; Saha, M.S.

We report preliminary results from a prototype of radiation imaging technology which takes advantage of the emission properties of the radioisotope iodine 125I as the probe. The detector system utilizes crystal scintillators and a position sensitive photomultiplier tube. Iodine 125 decays via electron capture emitting a 35-keV gamma ray with the prompt emission of several 27-32-keV Kα and Kβ shell X-rays. Because of this, a coincidence condition can be set to detect the 125I decay, thus reducing background radiation contribution to the image. The prototype detector we report has a limited sensitivity and detection area because of the size of the scintillators and photomultiplier tubes, yet it performed well enough to demonstrate the viability of this method for imaging 125I in a mouse. Mouse imaging studies of iodine uptake by the thyroid and melatonin binding have been done with this detector system using doses of 125I alone or attached to the melatonin. Many studies in molecular biology follow the expression and regulation of a gene at different stages of an organism's development or under different physiological conditions. Molecular biology research could benefit from this detection system by utilizing 125I-labeled gene probes

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Nuclear Science, IEEE Transactions on  (Volume:45 ,  Issue: 3 )