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RNA-Seq Analysis Pipeline Based on Oshell Environment

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5 Author(s)
Jing Li ; Div. of Bioinf., Omicsoft Corp., Cary, NC, USA ; Jun Hu ; Newman, M. ; Kejun Liu
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Advances in transcriptome sequencing (RNA-Seq) have revolutionized the way to characterize and quantify transcripts. The breakthroughs in RNA-Seq technologies give rise to the ever-increasing volumes of data, making data processing the bottleneck of transcriptome research. It becomes crucial to develop an efficient analysis pipeline to automate RNA-Seq data analysis. Based on Oshell environment, we present here an ultra-fast and powerful RNA-Seq analysis pipeline for quality control, sequence alignment, variation detection, expression quantification and junction discovery. The pipeline runs on both Linux and Windows operating systems, with either stand-alone or cluster computing environment. Parallel computing is also supported for improved processing speed. Oshell is free for non-commercial use at

Published in:

Computational Biology and Bioinformatics, IEEE/ACM Transactions on  (Volume:11 ,  Issue: 5 )