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This paper discusses the design and implementation of a family of mixed-signal neural network integrated circuits for general and application-specific purposes. Regular arrays of a nonlinearly-loaded multiplier block form the core of multilayer neural networks. Input-output circuitry and network size, however, vary depending on design applications. Some features of the present architecture are highlighted through experimental study, namely, low characteristic variations and self-scaling property of neurons and reduced interconnection problems and areas on silicon. Other design issues such as supply voltage reduction and pin limitations are discussed together with fabrication test results.