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Future Internet applications raise the need for infrastructures that can facilitate real-time and interactivity without major modifications in the application domain. Such infrastructures should be able to efficiently adapt resource provisioning to the dynamic demands of the applications, the majority of which tends to be real-time and interactive, posing specific Quality of Service (QoS) requirements. In this context, we present initial experimentation outcomes of a set of mechanisms (namely QoS-oriented Service Management mechanisms) that aim at enabling the provision of QoS guarantees in cloud infrastructures. They incorporate an orchestration framework that allows for workflow management in the case of non-monolithic applications, an adaptable monitoring mechanism that collects and aggregates monitoring information from application and infrastructure levels, and an evaluator service enabling runtime adaptability through provisioning policies. We also demonstrate the operation of the implemented mechanisms and evaluate their effectiveness in a large-scale multi-site cloud facility.