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The sensitivity of single-event effects (SEEs) in nanoscale CMOS for body-biasing circuits has been investigated. For PMOS hits, it is found that forward-biasing the body for high-speed applications can suppress the SET pulses greatly. Reverse-biasing the body for low-power applications, however, does not reduce the SEE vulnerability compared with operation when the body grounded. The body-biasing voltage has no impact on SEE sensitivity for NMOS hits.