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Two high static gain step-up dc-dc converters based on the modified SEPIC converter are presented in this paper. The proposed topologies present low switch voltage and high efficiency for low input voltage and high output voltage applications. The configurations with magnetic coupling and without magnetic coupling are presented and analyzed. The magnetic coupling allows the increase of the static gain maintaining a reduced switch voltage. The theoretical analysis and experimental results show that both structures are suitable for high static gain applications as a renewable power sources with low dc output voltage. Two experimental prototypes were developed with an input voltage equal to 15 V and an output power equal to 100 W. The efficiency at nominal power obtained with the prototype without magnetic coupling was equal to 91.9% with an output voltage of 150 V. The prototype with magnetic coupling operating with an output voltage equal to 300 V, presents an efficiency at nominal power equal to 92.2%.