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The National Program on Nanotechnology (NPNT), launched in 2003, is a landmark project in Taiwan to promote the scientific and technological development of the country's academic and industrial sectors. This article will provide an overview of the NPNT, including the missions, research and technology achievements, academia-industry and international collaborations, and future goals. Through the effort made by the NPNT, the promotion of industrial investments and economic competitiveness will be fostered by a continuous industry revolution in terms of resource development and realization of academic research results in practical products. The ultimate goal of the commercialization of nanotechnology can be accomplished in Taiwan.